NAD+ 500mg
$55.00
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in every living cell and plays a critical role in cellular energy production and metabolic function. It helps drive the processes that convert nutrients into usable energy by supporting mitochondrial activity, which is why NAD+ is often associated with energy levels, cellular performance, and overall vitality.
Beyond energy metabolism, NAD+ is involved in key pathways related to cell repair, DNA maintenance, and healthy aging, including its role in activating enzymes such as sirtuins. Because NAD+ levels naturally decline with age, it has become widely recognized for its connection to cellular longevity, metabolic efficiency, and resilience to oxidative stress.
Not for human consumption. For laboratory use only.
NAD+ Clinical Evidence
A reference guide to published clinical studies and active trials for NAD+ and its precursors NMN and NR, compiled for research purposes.
Comparing NMN, NR & Nicotinamide Directly
The first human trial directly comparing the three main NAD+ precursors. NR and NMN both significantly increased blood NAD+ levels over 14 days. Nicotinamide had an acute short-term effect but did not sustain elevated NAD+ levels. NR also showed increased short-chain fatty acids (SCFAs) in gut microbe testing, suggesting potential gut health benefits.
NMN Improves Sleep & Walking Speed in Older Adults
Double-blind, randomized, placebo-controlled trial in healthy older adults aged 65–75. 250mg/day NMN for 12 weeks significantly increased blood NAD+ levels and improved both walking speed and sleep quality compared to placebo.
NMN & NR Effects on Skeletal Muscle Mass & Function
Systematic review and meta-analysis evaluating NMN and NR supplementation effects on muscle. Found significant improvements in muscle mass based on gait speed changes, reduced insulin resistance, and lowered liver enzyme (ALT) levels in middle-aged and older adults.
NR for Cognition & Long-COVID Recovery
Double-blind, placebo-controlled trial at Massachusetts General Hospital / Harvard Medical School. Evaluated 2000mg/day nicotinamide riboside (NR) for effects on NAD+ levels, cognitive function, and long-COVID symptoms including immune dysregulation and mitochondrial dysfunction.
Safety & Effectiveness of NAD+ Supplementation
Reviewed 10 randomized controlled trials across 6 databases. Concluded that NAD+ and its precursors have a consistently favorable safety profile with minimal side effects across all studies reviewed.
NMN Supplementation on Glucose & Lipid Metabolism
Reviewed 12 studies with 513 participants. Found NMN consistently elevated blood NAD+ levels across all studies. Effects on glucose and lipid markers were mixed, with researchers noting that more large-scale trials are needed to draw firm conclusions on metabolic outcomes.
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Product Stability During Transit
All ARC Peptides products are supplied in lyophilized (freeze-dried) form, a process that removes moisture while preserving molecular structure and stability.
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Upon arrival, products should be stored according to the recommended storage guidelines provided on the storage instructions page.
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Storage Instruction
All ARC Peptides products are manufactured using the lyophilization (freeze-drying) process. This advanced method removes moisture while preserving molecular stability, allowing peptides to remain stable for shipping and storage for up to 3–4 months before reconstitution.
Once peptides are reconstituted (mixed with bacteriostatic water), they must be stored in a refrigerator to maintain stability. After reconstitution, peptides typically remain stable for up to 30 days when properly refrigerated.
Lyophilization is a specialized dehydration process in which the peptide solution is frozen and then placed under low pressure. This causes the water to sublimate directly from solid to vapor, leaving behind a stable, crystalline peptide powder. This freeze-dried form can be stored at room temperature until it is ready to be reconstituted.
After receiving your peptides, it is recommended that they be kept cool, dry, and protected from light. If the peptides will be used within the next few weeks, refrigeration at or below 4°C (39°F) is generally sufficient. Lyophilized peptides are often stable at room temperature for short periods, making temporary storage acceptable prior to use.
For long-term storage (several months to years), peptides should be stored in a freezer at approximately −80°C (−112°F). Freezing helps preserve peptide integrity and stability over extended periods.