Retatrutide 20mg
Original price was: $120.00.$110.00Current price is: $110.00.
Retatrutide is a next-generation peptide designed to support advanced metabolic function and body composition goals. Often referred to as a “triple agonist,” it works on multiple pathways in the body to help regulate appetite, support energy balance, and promote fat loss.
Many users are drawn to Reta for its potential to enhance weight management efforts, support lean physique goals, and improve overall metabolic efficiency. Its unique multi-action approach makes it a standout option for those seeking more advanced support beyond traditional solutions.
For research and educational purposes only.
Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) developed by Eli Lilly. Phase 2 trials reported up to 24.2% mean body weight reduction at 48 weeks. The first Phase 3 result (TRIUMPH-4, December 2025) confirmed up to 28.7% weight reduction at 68 weeks. Additional Phase 3 readouts are expected throughout 2026.
Phase 3 — December 2025
TRIUMPH-4: Obesity + Knee Osteoarthritis
The first Phase 3 result for retatrutide. A 68-week, randomized, double-blind, placebo-controlled trial in 445 adults with obesity or overweight and knee osteoarthritis (no diabetes). More than 1 in 8 retatrutide-treated patients reported complete freedom from knee pain at week 68, versus 4.2% on placebo.
| Group | Weight Loss | Pain Reduction |
|---|---|---|
| Retatrutide 12mg | −28.7% | −4.4 pts |
| Retatrutide 9mg | −26.4% | −4.5 pts |
| Placebo | −2.1% | −2.4 pts |
Phase 2 — NEJM 2023
Obesity Phase 2 Trial
338 participants over 48 weeks. The foundational study establishing retatrutide's efficacy and safety profile across multiple doses.
Meta-Analysis — PMC 2024
Systematic Review of RCTs
Analysis of 878 patients across 3 randomized controlled trials. Covers weight, BMI, glucose, HbA1c, and safety outcomes.
Liver Disease — Nature Medicine 2024
MASLD (Fatty Liver) Phase 2a
First trial of retatrutide in metabolic-associated steatotic liver disease. 24-week data demonstrated significant liver fat reduction.
Body Composition — The Lancet 2025
DXA Body Composition Substudy
DXA imaging substudy in Type 2 Diabetes patients, measuring changes in fat mass, lean mass, and visceral fat composition.
Trial Design — PubMed 2024
TRIUMPH Phase 3 Program Design
Describes the design of the full Phase 3 basket trial program across obesity, sleep apnea, osteoarthritis, cardiovascular, and kidney conditions.
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Product Stability During Transit
All ARC Peptides products are supplied in lyophilized (freeze-dried) form, a process that removes moisture while preserving molecular structure and stability.
This allows peptides to remain stable during standard shipping conditions without the need for temperature-controlled packaging.
Upon arrival, products should be stored according to the recommended storage guidelines provided on the storage instructions page.
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Storage Instruction
All ARC Peptides products are manufactured using the lyophilization (freeze-drying) process. This advanced method removes moisture while preserving molecular stability, allowing peptides to remain stable for shipping and storage for up to 3–4 months before reconstitution.
Once peptides are reconstituted (mixed with bacteriostatic water), they must be stored in a refrigerator to maintain stability. After reconstitution, peptides typically remain stable for up to 30 days when properly refrigerated.
Lyophilization is a specialized dehydration process in which the peptide solution is frozen and then placed under low pressure. This causes the water to sublimate directly from solid to vapor, leaving behind a stable, crystalline peptide powder. This freeze-dried form can be stored at room temperature until it is ready to be reconstituted.
After receiving your peptides, it is recommended that they be kept cool, dry, and protected from light. If the peptides will be used within the next few weeks, refrigeration at or below 4°C (39°F) is generally sufficient. Lyophilized peptides are often stable at room temperature for short periods, making temporary storage acceptable prior to use.
For long-term storage (several months to years), peptides should be stored in a freezer at approximately −80°C (−112°F). Freezing helps preserve peptide integrity and stability over extended periods.